Research Personal Site
Matt Onsum
The application of mathematical modeling to improve decision-making in drug discovery and development.
Specialties:
Mathematical and computational biology, image processing, control theory, system identification, model validation, neutrophil chemotaxis
Research Interests
Senior Scientist in Systems Biology
AstraZeneca R&D Boston
35 Gatehouse Drive
Waltham, MA 02451
Invited Talks
Publications
Education
Systems Biology: A Multi-Disciplinary Approach to Improve the Drug Discovery and Development Process
Cook D, Scherrer D, Onsum M and Henney A
American Drug Discovery, 2(2):1-5, 2007
A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Onsum M, and Rao CV
PLoS Comp. Biol. 3(3):e36, 2007
Morphology Matters in Immune Cell Chemotaxis: Membrane Asymmetry Affects Amplification,
Onsum MD, Wong K, Herzmark P, Bourne HR and Arkin AP
Journal of Physical Biology, 3(3) 190-9, 2006
Model Discrimination using Data Collaboration
Feeley R, Frenklach MD, Onsum M, Russi T, Packard A, and Arkin AP
J. Phys. Chem. 110(21): 6803-6813, 2006
Numerical Computation of Diffusion on a Surface
Schwartz P, Adalsteinsson D, Colella P, Arkin AP, and Onsum MD
Proc Natl Acad Sci, 109(32):11151-6 , 2005
Autonomous Mobile Robot Control Based on White Blood Cell Chemotaxis.
Onsum MD, and Arkin AP
Computational Methods in Systems Biology, Second International Workshop. Paper appears in CMSB
Proceedings, Lecture Notes in Computer Science, Springer, 2004
“Mathematical modeling of biochemical signaling pathways: examples from neutrophil chemotaxis and drug discovery”, Pacific Institute of Mathematical Sciences, Vancouver, Canada, 2008
“Autonomous Mobile Robot Control Based on White Blood Cell Chemotaxis”, Computational Methods in Systems Biology, Second International Workshop. Paris, France, 2004
University of California, Berkeley, Berkeley, California
Ph.D., Mechanical Engineering, 2005
• Dissertation Title: “Analysis, Modeling, and Measurements of Immune Cell Chemotaxis: Receptor Asymmetry Affects Amplification”
• Major in control theory with minors in cell biology and computer science
•Advisors: Adam Arkin and Kameshwar Poolla
M.S., Mechanical Engineering, 2002
B.S., Mechanical Engineering, 2000