Matt Onsum

 
 

The application of mathematical modeling to improve decision-making in drug discovery and development.


Specialties:

Mathematical and computational biology, image processing, control theory, system identification, model validation, neutrophil chemotaxis

Research Interests

Principal Scientist in Systems Biology

Invited Talks

Publications

Education

Calling heads from tails: the role of mathematical modeling in understanding cell polarization

    Onsum M, and Rao CV

    Curr Opin Cell Biol. 21(1)74-81, 2009 


Systems Biology: A Multi-Disciplinary Approach to Improve the Drug Discovery and Development Processn

    Cook D,  Scherrer D, Onsum M and Henney A

    American Drug Discovery, 2(2):1-5, 2007


A Mathematical Model for Neutrophil Gradient Sensing and Polarization

    Onsum M, and Rao CV

    PLoS Comp. Biol. 3(3):e36, 2007 


Morphology Matters in Immune Cell Chemotaxis: Membrane Asymmetry Affects Amplification,

      Onsum MD, Wong K, Herzmark P,  Bourne HR and Arkin AP

     Journal of Physical Biology, 3(3) 190-9, 2006                                        


Model Discrimination using Data Collaboration

    Feeley R, Frenklach MD, Onsum M,  Russi T,  Packard A, and  Arkin AP

     J. Phys. Chem. 110(21):  6803-6813, 2006


Numerical Computation of Diffusion on a Surface

    Schwartz P, Adalsteinsson D, Colella P,  Arkin AP, and Onsum MD

    Proc Natl Acad Sci, 109(32):11151-6 , 2005


Autonomous Mobile Robot Control Based on White Blood Cell Chemotaxis.

    Onsum MD, and Arkin AP

    Computational Methods in Systems Biology, Second International Workshop. Paper appears in CMSB

    Proceedings, Lecture Notes in Computer Science, Springer, 2004

American College of Toxicology Annual Meeting, Palm Springs, CA, 2009


Biomedical Engineering Society Annual Fall Scientific Meeting, Pittsburg, PA, 2009


Engineering Cell Biology III, Santa Cruz, CA, 2009


Pacific Institute of Mathematical Sciences, Vancouver, Canada, 2008


Computational Methods in Systems Biology, Second International Workshop. Paris, France, 2004

University of California, Berkeley, Berkeley, California

     Ph.D., Mechanical Engineering, 2005

• Dissertation Title: “Analysis, Modeling, and Measurements of Immune Cell Chemotaxis: Receptor     Asymmetry Affects Amplification”

• Major in control theory with minors in cell biology and computer science

  1. Advisors: Adam Arkin and Kameshwar Poolla

     M.S., Mechanical Engineering, 2002

     B.S., Mechanical Engineering, 2000